Systemic fluconazole therapy and in vitro adhesion of Candida albicans to human buccal epithelial cells
- 1 January 1991
- journal article
- Published by Wiley in Journal of Oral Pathology & Medicine
- Vol. 20 (1) , 17-19
- https://doi.org/10.1111/j.1600-0714.1991.tb00881.x
Abstract
The adhesion of Candida albicans to buccal epithelial cells (BEC) from four healthy dentate men was studied in vitro 1 wk before, during and after a course of systemic fluconazole (50 mg once daily for 1 wk). After 1 wk of fluconazole intake candidal adhesion to BEC was significantly reduced and this reduction persisted for a week following completion of therapy. Fluconazole, therefore, in addition to being an effective antifungal agent may also have a sustained action on reducing adherence of candidal species to the oral mucosa.Keywords
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