Reaction of Benzoyl Isothiocyanate With Active Methylene Reagents: A Convenient Synthesis of Pyrazolo[5,4-c]pyrazole, 1,3-Oxazine, Thiazole and Pyrimidine Derivatives
- 1 January 1987
- journal article
- research article
- Published by Georg Thieme Verlag KG in Synthesis
- Vol. 1987 (03) , 228-231
- https://doi.org/10.1055/s-1987-27897
Abstract
Benzoyl isothiocyanate reacts with active methylene reagents e.g. ethyl cyanoacetate, malonitrile and acetylacetone to give, in each case, the corresponding 1:1 adduct 1, 13 and 14 respectively, Compound 1 was utilized for the synthesis of several heterocyclic derivatives. Compound 14 undergoes ready cyclization in basic medium to give the 1,3-oxazine derivative 15. The structures of the products were assigned and confirmed on the basis of their elemental analysis and spectral data.Keywords
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