Spinal-Fluid Gamma Globulin in Multiple Sclerosis and Other Neurologic Diseases

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Abstract
MULTIPLE SCLEROSIS is a disease of unknown cause with protean manifestations of involvement of multiple portions of the central nervous system. Because of the diversity of the lesions in the central nervous system, there are few, if any, pathognomonic symptoms and signs. In well-advanced disease, with a history of remissions and exacerbations, the diagnosis may not be difficult. During the early stages, however, many difficulties may be encountered in diagnosis. In an illness such as this, a laboratory test conceivably could be of great diagnostic aid. It is the purpose of this presentation to report on the value of paper electrophoresis of cerebrospinal-fluid proteins, particularly the gamma-globulin fraction, in multiple sclerosis. An increased gamma-globulin fraction in the cerebrospinal fluid in multiple sclerosis was recognized by Kabat and associates,1in 1942, using the free electrophoretic technique of Tiselius. Since that time, numerous investigators using paper electrophoretic,2-7immunochemical,8,9

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