Cytotoxicity of alkyl‐2‐cyanoacrylate adhesives

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Abstract
The cytotoxicity of methyl‐ and isobutyl‐2‐cyanoacrylate adhesives was determined using a rat polymorphonuclear leukocyte suspension. Cell degranulation increased and migration decreased on addition of the alkyl‐2‐cyanoacrylates to the suspension in a concentration‐dependent manner. When. acetylsalicylic acid or indomethacin, inhibitors of prostaglandin H Synthase, were present, the cytotoxicity observed on addition of the adhesives to the leukocytes decreased up to eightfold in a dose‐dependent manner as detected by trypan blue exclusion. Likewise, glutathione peroxidase and superoxide dismutase lowered such cytotoxicity resulting from the cyanoacrylates up to eight‐ and sevenfold, respectively. The data suggested that the adhesives may have generated prostaglandin and thromboxane biosynthesis, and participated in membranal oxidation and lysis. Such a mechanism may contribute to under standing the thrombotic events associated with the necrosis observed on application of these adhesives to tissues in vivo.

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