THE CLINICAL SIGNIFICANCE OF LACTIC DEHYDROGENASE ACTIVITY OF SEROUS EFFUSIONS

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Abstract
Malignant neoplastic cells in vitro and in vivo contribute lactic dehydrogenase activity to the fluid medium which bathes the cellular elements. Pleural and peritoneal effusions containing or in contact with malignant cells and/or tissue have lactic dehydrogenase activity greater than the plasma (or serum) from which the serous fluids are derived. Serous effusions obtained from patients without neoplastic disease have lactic dehydrogenase activity lower than the plasma (or serum) from which the effusions are derived. The clinical variations and implications of these generalizations are discussed in light of employing the enzymatic technique for the diagnosis of effusions containing malignant cells.

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