Influence of 4 different membrane oxygenators on inflammation-like processes during extracorporeal circulation with pulsatile and non-pulsatile flow

Abstract
The influence of four different membrane oxygenators (HF 4000, BOS-CM50, CML 2, Maxima) on leucocyte count, concentrations of PMN-elastase,clotting factor XII, AT-III, C1-INH, alpha 2-antiplasmin and C3a wasregistered before, during and after CPB with pulsatile and nonpulsatileflow in 80 male patients aged between 36 and 67 years. With all systemstested, there was a drop in the concentrations of clotting factor XII,AT-III, C1-INH and alpha 2-antiplasmin in the early extracorporealcirculation (ECC) phase, exceeding the average hematocrit reductionaccounted for by dilution. This drop was the least distinct with CML 2systems, both with pulsatile and nonpulsatile perfusion, indicatingsystem-inherent influences. Leucocyte cound and PMN-elastase concentrationrose significantly during ECC irrespective of oxygenator tested of flowtype applied. The rise in leucocyte count even continued for about 4 hafter ECC. During the first 40 min of ECC, these changes were paralleled bya significant rise in C3a concentration, suggesting complement activationas a main cause for PMN activation. However, there is reason to supposeinvolvement of further mechanisms operating in PMN activation, since theelevated C3a-concentrations began to fall off while leucocyte count andPMN-elastase concentrations were still increasing.

This publication has 0 references indexed in Scilit: