Tribulusamide A and B, New Hepatoprotective Lignanamides from the Fruits ofTribulus terrestris: Indications of Cytoprotective Activity in Murine Hepatocyte Culture
- 1 October 1998
- journal article
- research article
- Published by Georg Thieme Verlag KG in Planta Medica
- Vol. 64 (07) , 628-631
- https://doi.org/10.1055/s-2006-957535
Abstract
Tribulusamides A (1) and B (2), new lignanamides embracing two cinnamic amide parts joined in a cis configuration, were isolated from the fruits of Tribulus terrestris, together with four known compounds, N-trans-feruloyltyramine (3), terrestriamide (4), N-trans-coumaroyltyramine (5), and β-sitosterol. The structures were elucidated by 2D-NMR spectroscopy. Addition of compounds 1-5, especially 1 and 2, to primary cultured mouse hepatocytes significantly prevented cell death induced by D-galactosamine (D-GalN)/tumor necrosis factor α (TNF-α).Keywords
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