Effect of coenzyme analogues on enantioselectivity of alcohol dehydrogenase
- 1 January 1992
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 9,p. 1083-1084
- https://doi.org/10.1039/p19920001083
Abstract
Secondary alcohol dehydrogenase from Thermoanaerobacter ethanolicus catalyzes the reduction of butan-2-one with much higher enantioselectivity when NADP is replaced by APADP, SNADP or NAD; as expected, the enantiomeric ratios [(kcat/km)R/(kcat/km)s] of the reaction of SADH with (R)- and (S)-butan-2-ol increase with the coenzyme analogues.Keywords
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