Progesterone, 16a-Hydroxy-Progesterone, and Maintenance of Pregnancy In Mice.

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Abstract
Subcutaneous pellets of this compound did not affect the normal duration of pregnancy or survival of fetuses in intact mice. In mice implanted with 2 progesterone pellets (about 18 mg) of pure progesterone on day 12 of pregnancy and ovariectomized on day 14, fetal survival was good. If pellets of 16[alpha]-hydroxy-progesterone were substituted, total abortion promptly occurred. If the pellets were a mixture of 16[alpha]-hydroxy-progesterone and progesterone, some fetuses survived, the survival rate diminishing as the proportion of 16[alpha]-hydroxy-progesteronetoa fixed amount (about 18 mg) of progesterone increased.