The polyketide synthase (PKS) of aspyrone biosynthesis: evidence for the enzyme bound intermediates from incorporation studies with N-acetylcysteamine thioesters in intact cells of Aspergillus melleus
- 1 January 1991
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 16,p. 1110-1112
- https://doi.org/10.1039/c39910001110
Abstract
The intact incorporation of deuterium labelled N-acetylcysteamine thioesters of crotonic, (2E,4E)-hexadienoic and (2E,4E,6E)-octatrienoic acids into aspyrone support the hypothesis that the aspyrone polyketide synthase resembles a fatty acid synthase in its mode of operation, and that it follows a processive mode of operation.Keywords
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