STUDIES ON LOCAL TREATMENT OF RABIES-INFECTED WOUNDS

Google Scholar
  • 1 January 1963
    • journal article
    • research article
    • Vol. 28  (4) , 477-+
Abstract
Local treatment of wounds infected with rabies virus is a valuable adjunct to the use of antiserum, vaccine or both in preventing disease. The studies on experimental animals reported in this paper evaluate methodology in treatment; evaluate the effectiveness of various substances, including antirabies serum, soap and benzalkonium chloride; and explore the possible role of blocking agents in preventing rabies. Certain oil-based local anaesthetics, almond oil, benzyl alcohol and benzalkonium chloride, interfere with motor function and exert a marked sparing effect when inoculated intramuscularly above the site of infection; aqueous or slanie-based local anaesthetics and saline do not interfere and fail to protect. The role of blocking agents, if any, in preventing rabies in man is unknown.