Effects of a Thio Analog of Platelet-Activating Factor on Platelet Aggregation and Adenosine 3′,5′-Monophosphate Concentration in Hepatocyte Suspensions and in Platelets. A Comparison with the Naturally Occurring Compound

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Abstract
2-Acetyl-S-octadecyl-racemic-1-thioglycero-3-phosphocholine, the thio analog of platelet-activating factor, in concentrations of 10-6 M-10-12 M in the medium, lowers cAMP-concentrations in rat hepatocytes. In a concentration of 10-4 M, the thio analog aggregates human platelets irreversibly; above 10-5 M, aggregation shows a reversible course. Compared with the saturated or unsaturated ether analogs, the thio compound shows less platelet-aggregating potency. This difference was correlated in platelet aggregation with reduced cAMP-depressing activity of the thio analog (compared with saturated and unsaturated 2-acetyl-1-O-alkyl-sn-glycero-3-phosphocholines).

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