STAPHYLOCOCCAL ANTAGONISM TO PENICILLIN-G THERAPY OF HEMOLYTIC STREPTOCOCCAL PHARYNGEAL INFECTION

1 March 1963

journal article
Published by American Academy of Pediatrics (AAP) in Pediatrics

Vol. 31 (3) , 463-469
https://doi.org/10.1542/peds.31.3.463

Abstract

Twelve pharyngeal specimens containing both group A hemolytic streptococci and coagulase-positive staphylococci were tested individually and together against penicillin-G and oxacillin. The hemolytic streptococci were always completely inhibited at very low concentrations of penicillin-G when tested individually. When combined with cultures of coagulase positive. penicillin-G destroying staphylococci, the inhibitory concentrations rose by a factor of 200. Similar tests with oxacillin showed no increase for inhibitory or bactericidal concentrations when the organisms were tested singly or in combination. Penicillin-G resistent staphylococci seemed to protect group A hemolytic streptococci from the action of penicillin-G. This was not the case when oxacillin was exhibited.

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