Analysis of microtubule-associated protein 1a gene in hereditary spastic paraplegia

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Abstract
Disturbance of MAP structure or function could contribute to degenerative neurologic disorders such as hereditary spastic paraplegia (HSP). HSP is characterized by axonal degeneration that is maximal in the terminal portions of the longest descending and ascending axons in the CNS: crossed and uncrossed corticospinal tracts to the legs, fasciculus gracilis fibers, and to a lesser extent spinocerebellar fibers (see Fink et al.2 for review). Distal degeneration of CNS axons suggests that the primary disturbance of HSP may involve abnormal axonal transport, neurotrophic factors, their receptors, or impaired maintenance of axonal cytoskeleton. Loci for autosomal dominant HSP are present on chromosomes 2p, 14q, and proximal 15q (see Fink et al.2 for references). MAP1a has been localized to proximal chromosome 15q by somatic cell hybrid mapping, and was sublocalized using a chromosome 15 deletion hybrid panel.3 We …

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