Serum Cholesterol and Cancer — A Retrospective Case-Control Study

Abstract
The time relationship between low serum cholesterol and the subsequent development of malignant neoplasms was examined in a case-control study of 100 cases of cancer death and 393 controls. The serum cholesterol levels were followed by repeated blood analysis over a 16-year period. An association between low serum cholesterol and cancer death was found particularly for malignant neoplasms of the large intestine and rectum. This relationship diminished 7–16 years prior to death suggesting that the low serum cholesterol levels were an effect of the cancer in an early stage and not vice versa.