DNA-Dependent Dye Binding by Oral Epithelium

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Abstract
Significant increases in the uptake of the dye by cells of heavy cigarette smokers and pipe smokers was observed. There was a close relationship between the degree of dye binding and the quantity of cigarettes consumed. Cigar smokers showed little deviation from the values obtained for nonsmokers. The correlations which were observed were consistent with existing information on the associations between smoking and respiratory tract neoplasia, pointing to a possible action upon DNA metabolism as fundamental in smoking-induced carcinogenesis.