Some experimental design and analysis considerations for cytogenetics studies

1 January 1985

journal article
research article
Published by Wiley in Environmental Mutagenesis

Vol. 7 (S4) , 9-15
https://doi.org/10.1002/em.2860070804

Abstract

Cytogenetic analysis has been used for several years in attempts to detect the mutagenic effects of suspect agents. Yet there remain many questions related to statistical analysis. While several procedures have been and are being used, many unfortunately are not always appropriate for the types of data actually obtained. Two general analysis approaches are discussed together with ways to insure that the test assumptions are reasonably met. Because assay sensitivity is a major concern, the sample size issue is discussed with examples for specific situations.

Keywords

This publication has 5 references indexed in Scilit:

Variations in the proportion of abnormal cells and required sample sizes for human cytogenetic studies
Mutation Research/Environmental Mutagenesis and Related Subjects, 1979
Contingency tables and the chi-square test
Published by Springer Nature ,1977
Experimental statistics
Published by National Institute of Standards and Technology (NIST) ,1963
On estimating binomial response relations
Biometrika, 1956
Transformations Related to the Angular and the Square Root
The Annals of Mathematical Statistics, 1950