Some Aspects of the Pharmacology of Para-Aminosalicylic Acid

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Abstract
Summary: Acute and chronic toxic doses of p-aminosalicylic acid to mice have been determined by various routes of administration. Prolonged oral and subcutaneous administration to mice produces some pathological effects on the liver and kidney. A method is described for the estimation in blood and urine, and blood levels curves are given in mice and man. Caronamide has no effect on the blood levels in man. It appears to have no hypoprothrombinæmic or antipyretic effect in rabbits. It exerts a protective effect in mice infected with M. tuberculosis H37 Rv, but it is not so effective an antitubercular drug as streptomycin. My grateful thanks are due to my colleagues Mr. A. S. Beach, Mr. J. H. Marvin, Mr. T. R. Middleton and Mr. C. R. B. Williamson for their assistance in this work, and I am indebted to the Directors of British Chemicals and Biologicals Ltd., for permission to publish this paper.

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