Site of airflow obstruction in immediate and late reactions to bronchial challenge with Dermatophagoides pteronyssinum

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Abstract
The density dependence of maximum flow in 10 atopic asthmatics was assessed by response to breathing a He-O2 mixture. They were then subjected to bronchial challenge by D. pteronyssinus and density dependence re-assessed during early and late bronchial reactions. There was considerable individual variation in the density dependence before challenge and in the change in density dependence during induced bronchospasm. For any given individual the results were similar during early and late reactions. The major site of airflow obstruction may vary from 1 asthmatic to another but that when antigen challenge is followed by a dual early and late reaction the site of obstruction is similar at each stage.