Haloperidol, Fluphenazine and Clonidine in Tourette Syndrome: Controversies in Treatment

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Abstract
The value of haloperidol, fluphenazine and clonidine as therapeutic agents for Tourette’s syndrome was retrospectively reviewed. Haloperidol improved tic symptoms in 50/60 patients, but side effects often nullified these benefits. Fluphenazine was an effective drug for tic suppression in 24/31 patients. Direct comparison of these drugs in 23 patients confirmed the efficacy of fluphenazine and showed it to produce fewer adverse effects than haloperidol. Clonidine was helpful in 47% and caused few side effects. These results support the use of clonidine for the treatment of tics and suggest that fluphenazine can be considered an alternative to other neuroleptic drugs.

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