A New, One-Pot (E) -Stereoselective Synthesis of Racemic and Chiral α,β-Unsaturated Sulfoxides from Sulfinates and Lithium Dimethyldiphenylphosphonium Diylide
- 1 January 1991
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 1991 (12) , 913-915
- https://doi.org/10.1055/s-1991-21988
Abstract
α,β-Unsaturated sulfoxides 6 with (E)-geometry, both racemic or optically active, were effectively synthesized by the one-pot reaction of lithium dimethyldiphenylphosphonium diylide [1; lithiomethyl(methylene)diphenylphosphorane] with sulfinates 2 followed by treatment of the α-sulfinylmethylmethyldiphenylphosphonium ylide formed [4; methyldiphenyl(sulfinylmethylene)-phosphorane] with aldehydes.Keywords
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