Mapping of the Pneumococcus Chromosome. Linkage between the Genes Conferring Resistances to Erythromycin and Tetracycline and Its Implication to the Replication of the Chromosome

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Abstract
In the process of constructing a map of the pneumococcus chromosome by transformation, a search for linkage groups involving the markers ery-ra, str-rqr, amiA-rr, opt-ra and tet-A has been carried out. No linkage was found amongst the first four markers, but linkage was found between ery-ra and tet-A. The dis- crepancy between these results and the previously reported linkage between the loci conferring resistance to erythromycin and streptomycin is discussed. The anoma- lous position of the ery-ra-tet-A linkage in relation to the chromosomemap obtained by the density-shift method, and the implications to the mode of replication of the chromosome, are discussed. Two models are proposed for the replication of the pneumococcal chromosome.

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