Preclinical and Phase I Studies of Malonatoplatinum
- 1 January 1980
- book chapter
- Published by Springer Nature
- Vol. 74, 156-162
- https://doi.org/10.1007/978-3-642-81488-4_20
Abstract
After a preclinical toxicologic study in baboons, we are conducting a phase I trial of malonatoplatinum, starting with 3 mg/kg and now reaching 16 mg/kg. Toxicity, mainly hematologic, was mild and our study was mainly limited by poor solubility. Regressions, which have been rare in the advanced-tumor patients, have been observed in three patients considered as clinically resistant to cisdichlorodiammino- platinum (DDP). Malonatoplatinum pharmacokinetics appeared similar to those of DDP as far as total platinum is concerned.Keywords
This publication has 2 references indexed in Scilit:
- Preclinical and Phase I Studies of MalonatoplatinumPublished by Springer Nature ,1980
- Cisplatin (cis-diamminedichloroplatinum II)Cancer Treatment Reviews, 1979