Effects of haemolysed blood and adenosine diphosphate on the pulmonary vascular resistance in calves

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Abstract
In newborn calves a portion of the pulmonary circulation was perfused at constant rate of flow to assess pulmonary vasomotor changes. Haemolysed blood and adenosine diphosphate (ADP) elevated the pulmonary vascular resistance. This effect was reversed by isoprenaline which also counteracted hypoxic pulmonary vasoconstriction. It is suggested that haemolysis releases ADP and that this has a vasoconstrictor effect on the pulmonary circulation.