Quality Control Testing with the Disk Antibiotic Susceptibility Test of Bauer–Kirby–Sherris–Turck

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Abstract
During two 6-month periods, daily quality control procedures for the single high potency disk diffusion antibiotic sensitivity test were monitored for 16 frequently used antibiotics using control strains of Escherichia coli and Staphylococcus aureus. During the first 6-month period disks were stored at 4 to 10 C. Disks were stored in a frozen condition (–20 C.) during the second 6-month period. Testing during the first 6-month period showed greater day-to-day variability than during the second 6-month period. Zone sizes were within a 4 mm. range in 98% of tests with E. coli for all antibiotics tested with the exception of sulfisoxazole, and were within a 4 mm. range for S. aureus in 94% of tests with the exception of lincomycin. The acceptable range for lincomycin has been modified to 6 mm. Testing was performed by 13 individuals, and the results demonstrate the practicality, accuracy, and reproducibility of this method when carried out by a well standardized method in the clinical laboratory.

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