Relation of Survival Time to Implantation Time of Second Set Skin Homografts in the Rat.

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Abstract
The relation of survival time to implantation time of 2d set homografts in the rat was studied. The conditioning 1st graft and the subsequent 2d and 3d set grafts were always obtained from the same donor and were sutured into defects of the same size made in the skin of the host. Second set homografts implanted simultaneously with, or 5 days after the 1st set graft, develop an active hemal circulation and are rejected simultaneously with 1st set graft. Second set homografts implanted 6 or 7 days after 1st set graft never become revascularized and are considered to survive for zero days. Second set homografts implanted 8-30 days after 1st set graft develop an active hemal circulation and survive for a mean time of 5.1 days. Second set homografts implanted 60 days after 1st set graft show a normal 1st set survival time of 8 days. There is no significant difference between survival time of 2d and 3d set grafts when 3d set is implanted 7 days after the 2d set graft. It is concluded that temporal sequence in accelerated breakdown of 2d set skin homografts is suggestive of an immunological mechanism triggered by the host''s contact with the 1st set graft.