Influence of Liquid Bonding Strength on Power Consumption During Granulation in a High Shear Mixer
- 1 January 1988
- journal article
- research article
- Published by Taylor & Francis in Drug Development and Industrial Pharmacy
- Vol. 14 (8) , 1041-1060
- https://doi.org/10.3109/03639048809151919
Abstract
A comparison between the effects of different binders on power consumption and -granule growth by granulation in a Fielder PMAT 25 high shear mixer demonstrates that the power consumption is influenced by the intra-granular porosity and the surface tension of the binder solution. It is suggested that the effects are due to a correlation between the power consumption and the strength of mobile liquid bondings in the moist agglomerates. It is shown that the power consumption reflects the change of the intragranular porosity for a particular granulation process with dicalcium phosphate.This publication has 5 references indexed in Scilit:
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- Mechanical properties of moist agglomerates in relation to granulation mechanisms part I. Deformability of moist, densified agglomeratesPowder Technology, 1985
- Mechanical properties of moist agglomerates in relation to granulation mechanisms part II. Effects of particle size distributionPowder Technology, 1985
- Granulation in high-speed mixers Part V. Power consumption and temperature changes during granulationPowder Technology, 1985
- The determination of the contact angle for systems with a powderChemical Engineering Science, 1965