Increased water drinking follwing repeated exposures to toluene vapor in rats.

Publisher Website
Google Scholar
Abstract
Repeated inhalation exposures of rats to 900 ppm and 2700 ppm of toluene vapor produced a dose-related increase in drinking behvior and daily water intake with an increase in both the vapor concentration and number of the repeated exposures. A dose-related increase in plasma osmolality and plasma sodium concentration with a concomitant decrease in plasma protein concentration was found in the rats sacrificed 4 hours after cessation of the repeated expsoures for 3 weeks to 900 ppm and 2700 ppm of toluene vapor. More positive water balance, increased urine volume, lowered urine osmolality without a significant increase in urinary sodium and potassium excretions occurred on Day 1 following repeated exposures to toluene vapor for 3 weeks. The present blood and urine data indicated that the plydipsia induced by repeated exposure to toluene vapor was related to the increase in both plasma sodium concentration and plasma osmolality.