THE BASOPHILIC AGGREGATION TEST IN LEAD POISONING

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Abstract
The testing of the blood in lead poisoning by the basophilic aggregation method is based on the fact that the developmental period of red cells within bone marrow may be interrupted under conditions of physiologic need or pathologic changes in the bone marrow. These conditions that make demands on the bone marrow lead to the appearance in the peripheral circulation of red cells in varying stages of immaturity. The nucleated red cell is characteristic of marked immaturity. The transition to maturity is marked by the extrusion from the red cell of a single highly refractile body, recently described by Isaacs.1 CHARACTERISTICS OF YOUNG ERYTHROCYTES In addition to these two characteristics, other qualities serve to distinguish these young erythrocytes from old ones. The premature red cell is usually larger than the mature one in the same preparation.2 Immature red cells contain a basophilic substance, the nature of which is

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