Preparation of Highly Labeled [ 32 P]Nucleic Acids from Yeast; Isolation of "Denaturable" Leucine Acceptor Transfer RNA

Abstract
Culture conditions were developed that permit efficient incorporation of [ 32 P]phosphate into nucleic acids of baker's yeast. RNA sufficiently labeled for sequence determination was obtained in this way. Pure "denaturable" leucine acceptor transfer RNA (tRNA Leu 3 ) was isolated for this purpose.