POLYNEUROPATHIES AND CNS PROTEIN METABOLISM. II. CHANGES IN THE INCORPORATION RATE OF LEUCINE DURING ACRYLAMIDE INTOXICATION

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Abstract
The hypothesis of failure of neuronal cell body metabolism as the principal cause of acrylamide neuropathy is re‐examined. Protein synthesis was studied in rats during chronic intoxication with acrylamide in spinal cord, brain stem and heart during three phases of the intoxication. The incorporation of radioactivity into proteins was measured in vivo after injection of radioactive leucine or after incubation in vitro of tissue slices with the labelled precursor. A highly significant depression of incorporation of precursor was found which suggests a relation between the rate of incorporation of amino acids into protein and progress of acrylamide neuropathy.