The Rapid Adjuvant Effect in the Acquisition of Delayed Hypersensitivity to Low Molecular Weight Sensitizers in the Guinea Pig

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Abstract
Guinea pigs were substantially sensitized to the low molecular weight chemicals dinitrochlorobenzene (DNCB), paranitrosodimethylaniline (NDMA), Rhus extract and picric acid, by the injection of Freund’s complete adjuvant into a skin site primed several days previously with a borderline sensitizing concentration of the particular chemical. The adjuvant effect may occur in as little as two days. The skin site prepared with allergen need be present only during the early portion of the inductive phase of the hypersensitivity. It appears that enhancement takes place via a quantitative and/or qualitative stimulation of centrally-located clones of cells previously selected by antigen.

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