Intravenous administration of a transferrin receptor antibody-nerve growth factor conjugate prevents the degeneration of cholinergic striatal neurons in a model of Huntington disease.
- 13 September 1994
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 91 (19) , 9077-9080
- https://doi.org/10.1073/pnas.91.19.9077
Abstract
Intrastriatal injections of quinolinic acid induce a pattern of neuronal degeneration similar to that seen in Huntington disease. In the present study, nerve growth factor (NGF) crossed the blood-brain barrier in a dose-dependent fashion following intravenous infusion when conjugated to an antibody directed against the transferrin receptor (OX-26). Intravenous injections of the OX-26-NGF conjugate selectively prevented the loss of striatal choline acetyltransferase-immunoreactive neurons which normally occurs following quinolinic acid administration relative to control rats receiving vehicle or a nonconjugated mixture of OX-26 and NGF. These data demonstrate that a neurotrophic factor-antibody conjugate can prevent the degeneration of central NGF-responsive neurons following systemic administration.Keywords
This publication has 25 references indexed in Scilit:
- Blood-Brain Barrier Penetration and in Vivo Activity of an NGF ConjugateScience, 1993
- NGF receptor (p75)‐immunoreactivity in the developing primate basal gangliaJournal of Comparative Neurology, 1993
- Function and evolution in the NGF family and its receptorsJournal of Neuroscience Research, 1992
- Nerve growth factor selectively prevents excitotoxin induced degeneration of striatal cholinergic neuronesNeuroscience Letters, 1992
- Nerve growth factor affects11C-nicotine binding, blood flow, EEG, and verbal episodic memory in an Alzheimer patient (Case Report)Journal Of Neural Transmission-Parkinsons Disease and Dementia Section, 1992
- Anti-transferrin receptor antibody and antibody-drug conjugates cross the blood-brain barrier.Proceedings of the National Academy of Sciences, 1991
- Intraputaminal Infusion of Nerve Growth Factor to Support Adrenal Medullary Autografts in Parkinson's DiseaseArchives of Neurology, 1991
- Intracerebral implantation of nerve growth factor-producing fibroblasts protects striatum against neurotoxic levels of excitatory amino acidsNeuroscience, 1991
- Function of neurotrophic factors in the adult and aging brain and their possible use in the treatment of neurodegenerative diseasesNeurobiology of Aging, 1989
- Loss of nerve growth factor receptor-containing neurons in Alzheimer's disease: A quantitative analysis across subregions of the basal forebrainExperimental Neurology, 1989