PROSTAGLANDIN-VASOPRESSIN INTERACTIONS ON THE RENAL HANDLING OF CALCIUM AND MAGNESIUM

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  • 1 January 1984
    • journal article
    • research article
    • Vol. 230  (2) , 295-301
Abstract
The role of prostaglandins in the regulation of Na and H2O excretion has been widely studied, but little is known about the influence of prostaglandins (PG) on tubular handling of Ca, Mg or PO3. PGE2 and vasopressin may interact and influence reabsorption of Ca and PO3 in the cortical collecting duct. This study investigated the effect of meclofenamate (2 mg/kg), an inhibitor of PG synthesis, on the excretion of Ca, Mg and PO3. Experiments were performed in antidiuretic and H2O diuretic rats to examine potential PG-vasopressin interactions on the reabsorption of these ions by renal tubules. In antidiuretic rats given meclofenamate, urine osmolality increased urine flow and the fractional excretion of H2O, urea, Na, Ca and Mg decreased by 30 to 50%. In H2O diuretic animals, urine osmolality and urea excretion were unaltered after meclofenamate administration. Fractional excretion of Na, H2O, Ca and Mg declined .apprx. 50% in H2O diuretic rats given meclofenamate. Urinary excretion of PGE2 was not significantly different in H2O diuretic and antidiuretic rats averaging 262 .+-. 78 vs. 167 .+-. 35 pg/min, respectively. Meclofenamate significantly reduced urinary excretion of PGE2 in both groups. Renal PG apparently modulate renal tubular reabsorption of Ca and Mg, and Na and H2O.