Stereocontrolled total synthesis of methyl 12(S)-hydroxy-5Z,8E,10E-heptadecatrienoate

Abstract
A short and stereocontrolled synthesis of methyl (12S,5Z,8E,10E)-12-hydroxyheptadeca-5,8,10-trienoate (1), based on a Pd0–TlOH catalysed coupling reaction of the vinyl iodide (3) and the vinylborane (4) is described.

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