Exacerbation of Salmonella Enteritis Due to Ampicillin

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Abstract
ALTERATION of the normal intestinal flora with antibacterial agents may have harmful results. Antibiotic therapy has been implicated in the pathogenesis of pseudomembranous enterocolitis1 and enteric candidiasis.2 A patient with severe diarrhea was recently observed who had been given ampicillin as a symptom-free carrier of salmonella. Administration of the drug apparently led to suppression of the normal intestinal flora and to the unrestrained growth of a salmonella species that was resistant to ampicillin.Case ReportJ.S., an 18-year-old boy, was admitted to Syracuse City Hospital on March 20, 1968, because of abdominal cramps and bloody diarrhea. Between March 5 and . . .

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