COMPLEMENT FIXING ANTIBODIES IN TUBERCULOUS GUINEA PIGS

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Abstract
Antigen prepared by a method previously described was employed in complement fixation tests on sera from guinea pigs experimentally infected with tuberculosis. In animals infected with a known inoculum of a single strain, complement fixing antibodies appeared regularly and consistently at the second to third week, reached a peak at about the seventh week, and thereafter either remained constant till the twelfth week, or declined. In another series sera from animals infected with unknown inocula of bacilli from a wide variety of sources all showed antibodies ranging in titer from 1:16 to 1:1024 at the sixth week.

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