Mycoplanecins, novel antimycobacterial antibiotics from Actinoplanes awajinensis subsp. mycoplanecinus subsp. nov.. III. Structural determination of mycoplanecin A.

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Abstract
The structure of mycoplanecin A [shown to have antibacterial activity] was determined by analysis of chemical degradation products and by mass and 1H and 13C NMR spectrometries. Mycoplanecin A is a new cyclic peptide antibiotic composed of mol each of .alpha.-ketobutyric acid, glycine, L-leucine, L-proline, L-2-amino-5-methylhexanoic acid, N-methyl-D-leucin, N-methyl-L-threonine, methyl-L-proline and ethyl-L-proline and 2 mol of N-methyl-L-valine. Among these components, ethyl-L-proline is reported for the 1st time as a component of natural products. A newly developed mass analysis was introduced for differentiation of .alpha.-amino acids and their N-methyl derivative.