Toxins of Pseudomonas aeruginosa: New Perspectives
- 1 September 1983
- journal article
- review article
- Published by Oxford University Press (OUP) in Clinical Infectious Diseases
- Vol. 5 (Supplement) , S715-S722
- https://doi.org/10.1093/clinids/5.Supplement_4.S715
Abstract
Toxin A is a protein with a molecular mass of ∼66,000 daltons whose production is regulated by iron. The toxicity of toxin A is due to its ability to inhibit protein synthesis. A role for toxin A in infections due to Pseudomonas aeruginosa is supported by its extreme toxicity, its production by most clinical isolates, the decreased virulence of nontoxic mutants, and the results of immunologic studies of animals and humans.Keywords
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