Rolipram inhibits PAF‐induced airway microvascular leakage in guinea‐pig: a comparison with milrinone and theophylline
- 26 August 1992
- journal article
- research article
- Published by Wiley in Fundamental & Clinical Pharmacology
- Vol. 6 (6) , 247-249
- https://doi.org/10.1111/j.1472-8206.1992.tb00117.x
Abstract
Summary—The effects of 3 phosphodiesterase (PDE) inhibitors, rolipram (PDE IV), milrinone (PDE III) and theophylline (nonselective) on PAF (50 ng kg−1; iv)‐induced airway vascular leakage have been evaluated in guinea‐pigs. Rolipram (3–300 μg kg−1; iv) reduced the increase in permeability induced by PAF at all airway levels whereas milrinone (10–1000 μg kg−1; iv) and theophylline (30 mg kg−1; iv) were without effects. The anti‐leakage activity of rolipram may be of therapeutic value in asthma.Keywords
This publication has 5 references indexed in Scilit:
- Prospects for selective cyclic nucleotide phosphodiesterase inhibitors in the treatment of bronchial asthmaClinical and Experimental Allergy, 1992
- Phosphodiesterase inhibitors: new opportunities for the treatment of asthma.Thorax, 1991
- Effect of Antiasthma Drugs on Microvascular Leakage in Guinea Pig AirwaysAmerican Review of Respiratory Disease, 1989