Ocular Penetration of Amphotericin B

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Abstract
Introduction Amphotericin B is well established as a fungistatic agent1 that is effective in the treatment of several systemic mycotic infections.2 Experience with its use in fungus diseases of the eye, though apparently beneficial, has been limited.3-6 Two reports have been found in which amphotericin B was used in the treatment of postoperative mycotic intraocular infections.5,6 Whether amphotericin B penetrates the eye is unknown. Previous attempts to demonstrate such penetrations have been unsuccessful,3 and it has been stated that amphotericin B cannot be identified in intraocular fluids following parenteral administration.4 Recently a patient with postoperative mycotic endophthalmitis was observed in whom the use of intravenous amphotericin B resulted in a dramatic response with clearing of the infection. The clinical observation prompted laboratory studies of the intraocular penetration of amphotericin B in rabbits under experimental conditions. Case Report A 75-year-old white woman was first found

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