Association of genetic alterations of c-myc, c-fos, and c-Ha-ras proto-oncogenes in colorectal tumors

Publisher Website
Google Scholar
Abstract
Ne we also have observed decreased levels of expression in 13 percent (3/24) of the cases analyzed. Gene amplification appeared to be a rare event in these tumors and was found in 3/29 (10 percent) tumors for c-mycand in 1/29 (3 percent) for c-fos protooncogene. Curves for overall survival and for disease-free survival failed to show a significant tendency in these parameters to be poorer in tumors with alterations of gene expression for any of the proto-oncogenes analyzed. Despite the biologic importance of these genetic alterations in the etiology of colorectal tumors, levels of c-myc, c-fos, and c-Ha-rasgene expression separately or together cannot be considered as prognostic factors for clinical outcome of the disease. This work was supported by grant 507750/87 of the Conselho Nacional de Desenvolvimento Cientificoe Tecnologico. © The ASCRS 1992...