Artemisinin and the antimalarial endoperoxides: From herbal remedy to targeted chemotherapy
- 1 June 1996
- journal article
- review article
- Vol. 60 (2) , 301-+
Abstract
Artemisinin and its derivatives are endoperoxide-containing compounds which represent a promising new class of antimalarial drugs. In the presence of intraparasitic iron these drugs are converted into free radicals and other electrophilic intermediates which then alkylate specific malaria target proteins. Combinations of available derivatives and other antimalarial agents show promise both as first-line agents and in the treatment of severe disease.This publication has 104 references indexed in Scilit:
- The toxicity of artemisinin and related compounds on neuronal and glial cells in cultureChemico-Biological Interactions, 1995
- Faster Evaluation of Vital DrugsScientific American, 1995
- Synthesis and Antimalarial Activities of 12.beta.-Allyldeoxoartemisinin and Its DerivativesJournal of Medicinal Chemistry, 1995
- Progress in the research of artemisinin-related antimalarials: An updatePharmacy World & Science, 1994
- The binding of the antimalarial arteether to human plasma proteins in-vitroJournal of Pharmacy and Pharmacology, 1992
- Randomised trial of artesunate and mefloquine alone and in sequence for acute uncomplicated falciparum malariaThe Lancet, 1992
- Comparison of artemether and chloroquine for severe malaria in Gambian childrenThe Lancet, 1992
- Effects of artemisinin, dihydroartemisinin and arteether on immune responses of normal miceInternational Journal of Immunopharmacology, 1990
- The effect of combinations of qinghaosu (artemisinin) with standard antimalarial drugs in the suppressive treatment of malaria in miceTransactions of the Royal Society of Tropical Medicine and Hygiene, 1987
- A controlled clinical trial of artemether (qinghaosu derivative) versus quinine in complicated and severe falciparum malariaTransactions of the Royal Society of Tropical Medicine and Hygiene, 1987