THE ROLE OF HORMONES IN VIRAL INFECTIONS, II. ACCELERATION OF VIRAL ADSORPTION AND PENETRATION INTO CELLS TREATED WITH THYROID HORMONE IN VITRO
- 1 June 1962
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 48 (6) , 973-977
- https://doi.org/10.1073/pnas.48.6.973
Abstract
The rate of polykaryocyte formation was used to study the effects of thyroxine on the adsorption and penetration of the herpes simplex virus (HSV) into HEp-2 cells. Cells pretreated with 3 to 24 hours with thyroid extract adsorbed HSV and affected its penetration more rapidly than untreated cells. The thyroid hormone affects the rate of adsorption and penetration; it does not alter the titer of the virus. The effect of the thyroid hormone is exactly opposite of the effect of parathyroid hormone.Keywords
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