Fibrinogen-transmitted hepatitis; a controlled study

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Abstract
Fibrinogen was used in 12 patients with life-threatening bleeding states or severe hypofibrinogenemia. Three of these patients succumbed to their disease. The remaining nine patients were followed closely at monthly intervals by physical examination and a group of laboratory tests. Hepatitis developed in five patients, including one who never became jaundiced. Four patients received both whole blood and fibrinogen, and one received fibrinogen only. There were no deaths attributable to the hepatitis. Gamma-globulin prophylaxis in one patient was felt to be ineffective. The discriminate use of fibrinogen only in life-threatening hemorrhage states is urged.