Enzymes of Methionine Metabolism in Regenerating Rat Liver

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Abstract
Significant changes in the activities of the enzymes of methionine metabolism occur in the regenerating rat liver. The levels of methionine adenosyltransferase and cystathionine synthase increased immediately after partial hepatectomy. A secondary peak of activity was noted on the 8th postoperative day. In contrast, activities of 5-methyltetrahydrofolate homocysteine methyltransferase and betaine-homocysteine methyltransferase declined. This pattern of changes suggests that transsulfuration, rather than methionine conservation, is a major metabolic response in hepatic regeneration.