Heterogeneity of Muscle Energetics in Human Muscle Fiber Type Using 31P Nuclear Magnetic Resonance

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Abstract
To evaluate the association between muscular phosphate metabolites or intracellular pH at rest and muscle fiber composition of musculus vastus lateralis in human, we measured phosphorus nuclear magnetic resonance (31P NMR) spectra and performed muscle biopsy in 30 subjects. The intracellular pH tended to be higher in cases with a higher percentage of fast-twitch fibers (% FT fibers). On the other hand, no relationship was observed between phosphocreatine (PCr)/inorganic phosphate (Pi) and percent FT fibers. This is inconsistent with previously reported results of 31P NMR studies in animals. These results suggest that PCr concentration is the same for the two major fiber types (FT and slow-twitch [ST] fibers) of human skeletal muscle. Knowledge of which relationship between muscle fiber composition and intracellular pH accounts for our results awaits further investigation.

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