On predictions of free antibiotic (cefazolin) concentrations in extravascular fluids from ‘logarithmic mean serum concentrations’

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Abstract
It is shown that the ‘mean logarithmic serum concentration’ of an antibiotic is likely to under-estimate the true mean steady state concentration in serum and, consequently, also in extravascular fluids. The origin of this underestimation is purely mathematical, and it will therefore affect the predictions even if suitable corrections for protein binding are made.