First Synthesis of Methyl syn 3-CF3-Isoserinate
- 1 April 1996
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 1996 (04) , 399-400
- https://doi.org/10.1055/s-1996-5424
Abstract
A [2+2] cycloaddition of the trifluoromethyl aldimines 5 with a ketene provided stereoselectively the CF3-substituted β-lactam 4 in a 50 % yield. Further steps of ring opening and deprotections led to the methyl syn-3-CF3-isoserinate which is a new fluoro analogue of the C-13 side-chain of taxoids.Keywords
This publication has 0 references indexed in Scilit: