Involvement of Ca2+ in platelet‐derived growth factor‐induced expression of c‐myc oncogene in Swiss 3T3 fibroblasts
Open Access
- 22 July 1985
- journal article
- Published by Wiley in FEBS Letters
- Vol. 187 (1) , 43-46
- https://doi.org/10.1016/0014-5793(85)81210-2
Abstract
Addition of platelet‐derived growth factor (PDGF) to quiescent cultures of Swiss 3T3 fibroblasts rapidly increased the cytoplasmic free Ca2+ concentrations and afterwards the c‐myc mRNA levels. The concentrations of PDGF needed for both reactions were roughly the same. Moreover, the Ca2+ ionophores, A23187 and ionomycin, mimicked the actions of PDGF and increased the c‐myc mRNA levels. These results suggest that Ca2+ may be involved in the regulation of PDGF‐induced expression of the c‐myc gene.Keywords
This publication has 13 references indexed in Scilit:
- Functional role for c-myc in mitogenic response to platelet-derived growth factorNature, 1984
- Some mitogens cause rapid increases in free calcium in fibroblastsFEBS Letters, 1984
- Cell-specific regulation of the c-myc gene by lymphocyte mitogens and platelet-derived growth factorCell, 1983
- The human c-myc oncogene: Structural consequences of translocation into the igh locus in Burkitt lymphomaCell, 1983
- Control of the cytoskeleton by calmodulin and calmodulin-binding proteinsTrends in Biochemical Sciences, 1983
- Epidermal growth factor (EGF) and somatomedin C regulate G1 progression in competent BALB/c-3T3 cellsExperimental Cell Research, 1982
- T-cell mitogens cause early changes in cytoplasmic free Ca2+ and membrane potential in lymphocytesNature, 1982
- Isolation of biologically active ribonucleic acid from sources enriched in ribonucleaseBiochemistry, 1979
- Dual control of cell growth by somatomedins and platelet-derived growth factor.Proceedings of the National Academy of Sciences, 1979
- Induction of DNA synthesis in BALB/c 3T3 cells by serum components: Reevaluation of the commitment processProceedings of the National Academy of Sciences, 1977